Aspirin is good for the heart, but mostly if you are a man, reported the Daily Express . “The benefits of taking the drug to ward off heart attacks have been well documented but studies suggest the protective effects are mainly experienced by men”, the newspaper said.
The newspaper story is based on data from a review of studies where aspirin was used to prevent heart attacks both in people who have never had heart problems and in those who have. The researchers found that overall aspirin reduces the risk of non-fatal heart attacks, but appears to do this only in studies where the participants are predominantly male.
Anyone who has had been prescribed aspirin should not stop taking it on the basis of these results and before taking regular doses of aspirin, people should consult their doctor. More studies are needed before the implications for patients are known.
Drs Todd Yerman, Wen Gan, and Don Sin from the University of British Columbia, the James Hog Centre for Cardiovascular and Pulmonary Research, and St Paul’s Hospital in Vancouver conducted this research. The study was funded by the Canadian Institutes of Health Research, the Canadian Lung Association and the Heart and Stroke Foundation of Canada. The review is not fully published yet, but is available in a draft form online through the BioMed Central medical journal – BMC Medicine .
This was a systematic review of randomised controlled trials. The researchers pooled together the results of multiple studies that looked at the use of aspirin to prevent a first heart attack (primary prevention) both in people with risk factors for cardiovascular disease and those without, or where aspirin was used to prevent another cardiovascular event in those who have had a heart attack or stroke (secondary prevention).
The researchers were interested in whether the gender of people who took part in the studies was responsible for the variation that is seen in the results. They combined the results from studies that involved mainly women and those that involved mainly men to see whether there were differences in the prevention of non-fatal and fatal heart attacks using aspirin.
The researchers found that when all the studies were pooled together, aspirin reduced the risk of a non-fatal heart attack by 28% overall. When they grouped the studies by the predominant gender of their participants, they found that in the studies that mainly involved men, the reduction in risk was greatest – 38%, while in studies enrolling mainly women, the reduction in risk was 13% (and this was not statistically significant).
The researchers concluded that gender accounts for a lot of the variation that we see in the efficacy of aspirin in reducing heart attacks. They say that their findings support the idea that women “might be less responsive to aspirin than men”.
The take-home message is that anyone currently prescribed aspirin, particularly those in high risk groups, should not stop taking it. Anyone concerned about their heart and considering the regular use of aspirin should consult their doctor.
There are several points to keep in mind when interpreting this study: